| Cow (Nightmare Zone)AggressiveM | | | 40 | |
 CrabM | | 3 | 0 | Crabs |
| Crawling HandM | | | 124 | Crawling Hands |
 Crystal implingM | 10 | N/A | 0 | |
 Culinaromancer (Nightmare Zone)AggressiveM | | 25 | 164 | |
| CyclopsAggressiveM | | | 0 | Hill Giants |
| Cyclops (Catacombs of Kourend)AggressiveM | | | 456 | Hill Giants |
 Dad (Nightmare Zone)M | | | 242 | Trolls |
 DagannothAggressiveM | | 8 | 163 | Dagannoth |
| Dagannoth (Waterbirth Island)AggressiveM | | | 0 | Dagannoth |
 Dagannoth mother (Nightmare Zone)AggressiveM | | | 40 | Dagannoth |
 Dagannoth Prime (Deadman)AggressiveM | | 26 | 0 | Bosses, Dagannoth |
 Dagannoth Rex (Deadman)AggressiveM | | 26 | 0 | Bosses, Dagannoth |
 Dagannoth Supreme (Deadman)AggressiveM | | | 0 | Bosses, Dagannoth |
| DamisAggressiveM | | | 0 | |
| Damis (Nightmare Zone)AggressiveM | | | 40 | |
 Dark warriorAggressive | | | 0 | Dark Warriors |
| Dark wizardAggressive | | | 0 | |
 Deathly mageM | | | 40 | |
 Deathly rangerM | | | 40 | |
| DefilerAggressiveM | | | 0 | |
 Derwen (Deadman)AggressiveM | | 43 | 0 | |
 Dessourt (Nightmare Zone)AggressiveM | | | 50 | |
 Dessous (Nightmare Zone)AggressiveM | | | 950 | Vampyres |
 Dinky the drink trollAggressiveM | 140 | 51 | 160 | Trolls |
| Dire WolfAggressiveM | | | 657 | Wolves |
 Doom of MokhaiotlAggressiveM | | | 37.6K | Bosses |
 Double agentAggressiveM | | | 40 | |
 Dragon implingM | 10 | N/A | 0 | |
 Durial321 (Deadman)AggressiveM | | 28 | 0 | |
| DuskM | 450 | | 0 | Bosses, Gargoyles |
| Dust devilM | | | 0 | Dust Devils |
| Dwarf | | | 90 | Dwarves |
| Dwarf gang memberM | | | 40 | Dwarves |
 Earth implingM | 10 | N/A | 0 | |
 Eclectic implingM | 10 | N/A | 0 | |
 Elidinis' Warden (Deadman)AggressiveM | | 41 | 0 | |
 Elvarg (Nightmare Zone)AggressiveM | | | 3,189 | Green Dragons |
| Emissary BrawlerAggressiveM | | | 0 | |
 Energy spriteM | 60 | 0 | 0 | |
| Enormous TentacleM | 120 | 2 | 0 | |
 Essence implingM | 10 | N/A | 0 | |
 Essyllt (Nightmare Zone)AggressiveM | 320 | | 0 | |
 Evil Chicken (Nightmare Zone)M | | 21 | 40 | Birds |
| ExperimentM | | | 40 | |
 Fareed (Nightmare Zone)AggressiveM | | | 40 | |
| Fear reaperAggressiveM | | | 0 | |
| Feral VampyreM | | | 1,051 | Vampyres |
| Fire giantAggressiveM | | | 652 | Fire Giants |
 Fire giant (Realm of Memories) | 111 | | 0 | |